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Lappalainen J
It selectively inhibits PMA-induced NF-κB activation
InChiKey: BLMPQMFVWMYDKT-NZTKNTHTSA-N
as assessed by elevated plus-maze test
WEHI-345 (20 mg/kg
Pyridostatin TFA salt - CAS# 1085412-37-8 167 Lappalainen JPyridostatin, CAS No. 1085412 37 8, stabilizes G quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication and transcription dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G quadruplex formation. As a result, pyridostatin modulated the expression